A new research study finds an area in the human brain which responds to negative life events and bad experiences reacts differently in people suffering from depression as compared to non-depressed healthy individuals. The study was conducted at UCL Institute of Cognitive Neuroscience and published in Molecular Psychiatry. It found that habenula, a pea-sized area in the brain, functions abnormally in depressed individuals. In healthy non-depressed people this brain region was activated when they expected to receive an electric shock. In depressed individuals, however, the exact opposite happened and the activity of habenula actually decreased when they thought they would get a shock. This shows that in depressed people the brain reacts in a fundamentally different way.